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Getting started with lantern11 days ago
Introduction | Installation | Example data | Step 1: split dosages by local ancestry | Step 2: write per-ancestry GDS files | Step 3: ancestry-stratified gene tests | Further reading | Session information
Split intuition: matrix examples for two and more populations11 days ago
Overview | Part A: Two populations | A.1 Unphased (dosage) split — split_diploid() | A.2 Phased (haplotype) split — split_haplotype() | Part B: More than two populations | B.1 Unphased (dosage) split — split_diploid_multi() | B.2 Phased (haplotype) split — split_haplotype_multi() | B.3 Four- and five-population extension | Part C: GLA shrinkage — when ambiguous carriers dominate | Session information
Toy example: splitting a VCF + MSP file (two and more populations)11 days ago
Overview | Part A: Two populations | Part B: More than two populations (K = 4) | Session information
Real data: chr19 association testing with binary, continuous, and count phenotypes3 months ago
Overview | 1 Gene-group file and kinship | 2 Binary phenotype (family = binomial()) | 3 Continuous phenotype (family = gaussian()) | 4 Count phenotype (family = poisson()) | 5 Adjusting for covariates | 6 Where to get gene-group files for other species/builds | 7 Other ways to adapt this to your own data